A papal bull in 1475 opened the library and archive to study by scholars. Archival material was formally separated from the library in the early 17th century and entrusted to the Vatican Secret Archives (now called the Vatican Apostolic Archive).

According to its website, the Vatican Library “preserves over 180,000 manuscripts (including archival units), 1,600,000 printed books, about 9,000 incunabula, over 300,000 coins and medals, more than 150,000 prints, thousands of drawings and engravings, and over 200,000 photographs.”

The revamped website of the papal library, unveiled in 2020, also gives researchers and students free access to high-resolution digitized manuscripts, inventories, archival materials, coins, medals, and incunabula, which are books printed in Europe before the 16th century.